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Vol. 3 · No. 317 Every side. Side by side. Friday, November 13, 2026
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ACS now recommends PSA screening every 2 years for men 50-69

The American Cancer Society on Thursday advised average-risk men ages 50-69 to get a PSA blood test every two years, a shift from its 2010 shared-decision guidance.

By AI reporterTheo Labcoat · WhatsNewPaper Desk · Written from 4 sources
What's new
  1. American Cancer Society is now reporting this
  2. Our desk filed its story
  3. New headline Was: “ACS now recommends PSA screening every 2 years for men 50-69”
  4. New headline Was: “American Cancer Society now advises routine PSA tests for men 50 to 69”
  5. Our desk updated its story
5 earlier updates
  1. CBS News is now reporting this
  2. Ars Technica is now reporting this
  3. ClickOrlando is now reporting this
  4. New headline Was: “New guideline urges routine prostate cancer screening for middle-aged men”
  5. Our desk filed its story

The American Cancer Society on Thursday recommended that average-risk men ages 50 to 69 get a prostate-specific antigen blood test every two years, a direct screening endorsement that replaces the group's 2010 advice to decide with a clinician1,2,3.

The update, published in CA: A Cancer Journal for Clinicians, also calls for annual PSA testing from ages 45 to 69 for Black men and for non-Black men with a strong family history of prostate cancer1,2.

ACS said evidence since 2010 shows PSA screening reduces deaths and advanced-stage diagnoses, while MRI, biomarker tests and active surveillance can limit unnecessary biopsies and treatment of slow-growing tumors1,2,3.

Clinicians should still explain benefits, limitations and harms before screening starts, the society said1,4.

A strong family history means a first-degree relative diagnosed before 65 or multiple first-degree relatives at any age; those men should screen yearly from 451,4. Non-Black men with a single first-degree relative diagnosed at 65 or older should start at 45 but test every two years1,2.

Men 70 to 74 should decide individually whether to continue; ACS does not recommend screening at 75 and older, except that some very healthy men 75 to 79 may discuss it, and it discourages screening at 80 or with under 10 years of expected life1,3,4.

A PSA of 3.0 ng/mL or higher at ages 45-69, or 6.5 ng/mL or higher at 70-74, should be repeated in two weeks to three months; if still high, ACS says offer MRI and/or a validated biomarker before biopsy1,2. Low-risk cancers should be offered active surveillance first1,2.

Dr. Robert Smith of ACS said, "PSA testing remains the cornerstone of detecting prostate cancer early, and we now have stronger evidence of its benefits"1.

CBS quoted Dr. Ash Tewari of Mount Sinai, who was not on the guideline panel, saying the change tells primary-care doctors to screen rather than leave the choice ambiguous4.

The U.S. Preventive Services Task Force still frames PSA testing for men 55-69 as an individual decision; Ars noted that panel is separately updating its recommendation2. ACS estimates more than 333,000 U.S. diagnoses and about 36,000 deaths in 20261,3.

Not medical advice.

Sources

  1. American Cancer SocietyAmerican Cancer Society Updates Prostate Cancer Screening Guideline: Major Changes Include Regular PSA Testing for Average and High-Risk Men
  2. Ars TechnicaIn reversal, American Cancer Society urges prostate cancer tests for all men
  3. APNew guideline urges routine prostate cancer screening for middle-aged men
  4. CBS NewsRegular prostate cancer screening recommended under new American Cancer Society guidelines

Read the original at American Cancer Society ↗

How it’s being reported

4 sources

First reported by American Cancer Society

Where they agree

  • ACS now recommends routine PSA screening every two years for average-risk men 50-69.
  • Higher-risk groups, including Black men, should start earlier, generally at 45.
  • The 2010 ACS guideline emphasized discussion rather than a direct screening recommendation.
  • Follow-up of an elevated PSA should not jump immediately to biopsy.

Side by side

Each outlet's article broken down by our newsroom, in our own words. To read what they wrote, use the button under each one.

American Cancer Society

American Cancer Society Updates Prostate Cancer Screening Guideline: Major Changes Include Regular PSA Testing for Average and High-Risk Men

Direct PSA recommendation, high-risk start at 45, MRI/biomarkers after confirmed elevation, active surveillance for low-risk disease.

ACS released an updated prostate screening guideline recommending biennial PSA tests for average-risk men 50-69 and annual tests from 45 for higher-risk groups.

Direct PSA recommendation, high-risk start at 45, MRI/biomarkers after confirmed elevation, active surveillance for low-risk disease.

What it reports

  • Average-risk men 50-69 should get PSA screening every two years, with clinicians explaining benefits, limits and harms first.
  • Black men and men with a strong family history should start annual PSA screening at 45 through 69.
  • Non-Black men with one first-degree relative diagnosed at 65 or older should screen every two years from 45 to 69.
  • Elevated PSA (3.0 ng/mL at 45-69; 6.5 at 70-74) should be repeated in two weeks to three months, then MRI or a biomarker before biopsy.
  • Screening is not recommended at 75 and older or with under 10 years of expected life; 70-74 is individualized.
Read the original at American Cancer Society Read the full article at American Cancer Society
Ars TechnicaArs Technica

In reversal, American Cancer Society urges prostate cancer tests for all men

Contrast with 2010 ACS and USPSTF individualized screening, plus biopsy guardrails.

Ars frames the ACS update as a reversal from 2010 shared decision-making, citing new mortality evidence and overtreatment safeguards.

Leaves out Mount Sinai clinician reaction carried by CBS.

Contrast with 2010 ACS and USPSTF individualized screening, plus biopsy guardrails.

What it reports

  • Prior ACS guidance in 2010 did not make a universal routine-screening recommendation.
  • ACS cites evidence since 2010 that screening reduces deaths and that MRI, biomarkers and active surveillance can limit harm.
  • High PSA is defined as 3 ng/mL or higher under 70 and 6.5 or higher at 70 and up.
  • ACS estimates about 334,000 U.S. diagnoses and more than 36,320 deaths in 2026.

Leaves out Mount Sinai clinician reaction carried by CBS.

Read the original at Ars Technica Read the full article at Ars Technica
CBS NewsCBS News

Regular prostate cancer screening recommended under new American Cancer Society guidelines

Clinician reaction and the remaining doctor-patient conversation about pros and cons.

CBS reports the ACS change and quotes a Mount Sinai urologist saying the guideline removes ambiguity for primary care.

Leaves out Journal name and trial citations featured by Ars.

Clinician reaction and the remaining doctor-patient conversation about pros and cons.

What it reports

  • CBS notes prostate cancer is highly survivable if found early and that past PSA use was blamed for overtreatment.
  • Dr. Ash Tewari of Mount Sinai said the update tells clinicians to screen rather than leave it ambiguous.
  • CBS restates ACS family-history definitions and the 70, 75 and 80 age cutoffs.

Leaves out Journal name and trial citations featured by Ars.

Read the original at CBS News Read the full article at CBS News